In Chile driving is on the right with overtaking on the left. You give way to vehicles on the right, however all corners will have street signs telling you what to do. You must stop at red lights. Driving is also relatively sane for a South American country. Drivers do tend to go fast though and you should stay clear of the white and yellow Micro mini buses. Most of the roads in the major urban areas of Chile are in good shape. However some streets outside the city centre are not so well maintained so you must drive very carefully.
